Citicoline is the body’s cell-membrane first-aid kit. Broken down in the gut to cytidine and choline, it rebuilds as CDP-choline inside neurons, patching phospholipid walls while donating choline to make the alertness transmitter acetylcholine. A single 500 mg dose can lift brain phosphodiester levels by 13% on ¹H-MRS within six weeks, and longer courses raise SIRT1—the cell-repair gene tied to healthy aging. Because native CDP-choline production falls with age and stress, topping up by mouth helps restore membrane integrity, signal speed, and neuronal energy—essentials for clear thinking across the decades.
Effectiveness4/5
Evidence4/5
Safety (general)3/5
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